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Moreover, (iv) the addition of GSH to isolated mitochondria rapidly reduces Grx1roGFP2 in the IMS (Figure 4) and (v) the absence of Glr1 hampers the redox state recovery after oxidative shock of the IMSlocalized oxidoreductase Mia40 (Figure 8E)

Numerically fewer patients reported adverse events such as gynecomastia or agitation, though the differences failed to reach statistical significance, likely in part due to small sample size